Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 14th Global Conference on Nephrology and Infectious Diseases Singapore City, Singapore.

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infectiousdiseases@asiameets.com

Scientific Program Day 1

Day 1 :

  • Pediatric Infectious Disease

Session Introduction

Ali Hammed

Tishreen University Hospital, Syria

Title: Cerebral Venous Sinus Thrombosis as a complication of Primary Varicella Infection in a Child, Case report
Speaker
Biography:

Dr. Ali studied General medicine at the Tishreen University, Latakia and graduated as MD in 2018. He then joined the residency program at the Tishreen university hospital. He is researcher and  research program leader at TUH. He is reviewer at Reviewer at Elsevier, BMC, Frontiers, Journal of oncology and Medicine.

Abstract:

Introduction and importance:

Chickenpox (Varicella) is a benign illness caused by varicella-zoster virus, predominant in childhood. Chicken pox related neurological complications are seen in less than 1% cases of chickenpox. Cerebral Venous thrombosis due to primary (VZV) infection  is very rare , and it may occurs secondary to primary or re-activation the virus.

Case presentation:

We report a case of 5-year-old female complained of  ataxia, vomiting, headache , and  drowsiness 7 days after the  onset varicella zoster infection. She had vesicular lesions with scab over the trunk and limbs.

Clinical Discussion:

Neurological examination revealed left hemiparesis. Her  blood counts and metabolic parameters were normal. Computed tomography brain showed hemorrhagic infarct in the left  temporo-parietal region. Coagulation profile was normal. Magnetic resonance imaging (MRI) brain revealed hemorrhagic infarct in the same region. Magnetic resonance Venogram showed thrombosis of left transverse sinus and sigmoid sinus and internal jugular vein. VZV- IgG antibody was positive but CSF VZV PCR (Polymerase chain reaction) was found to be negative. Intravenous acyclovir for 15 days, and low-molecular-weight heparin for 3 days  overlapped with oral Warfarin for 3months ,. After 3 months follow up, the patient experienced a complete recovery. MRI repeated after 3 months showed recanalization of the sinuses.

Conclusion:

The pathogenic link of occurrence of  CSVT after VZV infection is  unclear, but some articles showed that it is related to  direct endothelial damage by the virus. Early recognition of this complication of VZV infection and prompt treatment is essential to prevent catastrophic complications.

Solomon Ejigu

Mizan-Tepi University, Ethiopia

Title: Effect of Malaria and HIV/AIDS co-infection on Red Blood Cell Indices and Its relation with the CD4 level of Patients on HAART in Bench Sheko Zone, Southwest Ethiopia
Biography:

Solomon Ejigu, Department of Biomedical sciences, Collage of Medicine and Health science, Mizan-Tepi University, Mizan-Aman, Ethiopia.

Abstract:

Background

Malaria and HIV/AIDS are the two most common infections in sub Saharan Africa (SSA) and worldwide. HIV infected individuals in malaria endemic areas experience severe malaria episodes. The immunological basis of this clinical observation is unclear and the hematologic abnormalities such as anemia in malaria and HIV co infected patients were inconsistent from studies in the past. Ethiopia’s three-fourth of the landmass is malarious and HIV prevalence is high that significantly affect RBC indices and other hematologic profiles.

Objective: This study aimed to compare RBC indices and anemia in HIV patients’ co-infected with malaria and those HIV patients without malaria and correlates these with CD4 level.

Methods: A comparative cross-sectional study was employed on 103 malaria-HIV/AIDS co infected (MHC) and 103 HIV patients without malaria on HAART of the same ART centers in Bench Sheko Zone. Data was collected by structured questionnaire and blood samples were collected from both groups for malaria test and RBC indices measurement.  Data was entered and checked in Epi-data and exported to IBM SPSS version 21 software packages for analysis. 

Results There were significant differences in Mean±SD of RBC indices between the two groups (PË‚0.001). RBC, Hgb, HCT and MCV were lower in MHC patients.  In total study participants, significant positive correlation was observed between CD4 count with MCV, CD4 count with MCH and CD4 count with anemia.  In the group of malaria-HIV co-infected, CD4 count with RBC and CD4 count with Hgb and in HIV without malaria CD4 count with MCV, CD4 count with MCH and CD4 count with MCHC were positively correlated. Overall anemia prevalence was 45.1%. Anemia prevalence in MHC (Malaria-HIV co-infected) was 63.4 %. Anemia prevalence distribution among sex showed that 61.3 % in female sex and anemia prevalence distribution among CD4 group showed 55.9% in patients with CD4 count of ≤500 cells/μl.  Anemia in MHC patients was higher in those with CD4 count of ≤500 cells/μl (59.3 %) while in OH (Only HIV infected) anemia prevalence was similar in those with CD4 count of ≤500 and ≥500 cells/μl (50 %).  There is significant difference in anemia in MHC and OH infected with different CD4 group (PË‚0.01).

Conclusion: There was a difference in RBC indices in both groups; RBC, Hgb, HCT and MCV were lower in MHC patients. There was positive correlation between CD4 counts with some RBC indices in combined both groups. However, there was positive correlation between CD4 counts with RBC and Hgb in malaria-HIV co-infected. The combined prevalence of anemia was higher and anemia in MHC was greater than OH infected patients. 

Key words: CD4+ T cells, HAART, Malaria-HIV/AIDS co-infection, RBC indices, Anemia, Bench Sheko Zone.

 

  • Infectious Disease

Session Introduction

Uttam Ghosh

University of Calcutta, India

Title: Complex dynamics and control analysis of an epidemic model with non-monotone incidence and saturated treatment
Biography:

Department of Applied Mathematics, University of Calcutta, Kolkata-700009, India.

Abstract:

In this manuscript, we consider an epidemic model having constant recruitment of susceptible individuals with non-monotone disease transmission rate and saturated type treatment rate. Two types of disease control strategies are taken here, namely vaccination for susceptible individuals and treatment for infected individuals to minimize the impact of the disease. We study local as well as global stability analysis of the disease free equilibrium point and also endemic equilibrium point based on the values of basic reproduction number $R_0$. Therefore disease eradicates from the population if basic reproduction number less than unity and disease persists in the population if basic reproduction number greater than unity. We use center manifold theorem to study the dynamical behavior of the disease free equilibrium point for $R_0 = 1$. We investigate different bifurcations such as Transcritical bifurcation, Backward bifurcation, Saddle-node bifurcation, Hopf bifurcation and Bogdanov-Takens bifurcation of co-dimension 2. The biological significance of all types of bifurcations are described. Some numerical simulations are performed to check the reliability of our theoretical approach. Sensitivity analysis is performed to identify the influential model parameters which have most impact on the basic reproduction number of the proposed model. To control or eradicate the influence of the emerging disease, we need to control the most sensitive model parameters using necessary preventive measures. We study optimal control problem using Pontryagin's maximum principle. Finally using efficiency analysis, we determine most effective control strategy among applied controls.

  • Diagnosis, Management and Treatment of Infections

Chair

Kobra Salimiyan rizi

Isfahan University of Medical Sciences, Isfahan, Iran

Session Introduction

Kobra Salimiyan rizi

Isfahan University of Medical Sciences, Isfahan, Iran.

Title: The Smartphone biosensors for point-of-care detection of human infectious diseases
Biography:

The accurate and fast diagnosis of infectious diseases play a critical role in the timely and tailored treatment of the patients and preventing the infections from the spread. This is especially necessary in areas with low- and middle-incoming of the world. According to the smartphone-based sensory applications such as the inimitable ability to obtain portable, user-friendly, accurate, and effective functions, that in turn, converts lab-on-hardware an interesting area of new investigations. In the present review, original research articles published in English were collected from various databases during January 2011-July 2021. Also, the reference lists of the articles have been searched. In between 121 electronically searched citations, 35 articles had the inclusion criteria. The maximum potential and extended utilization of smartphone-based biosensors in the diagnosis of human infectious agents belonged to colorimetric smartphone biosensors. Also, because of their unique futures in easy visualization, comfortable analyzing and processing by smartphone, they are easier to use for point-of-care products. Based on the results, smartphone-based biosensors are rapid, precise, and low-cost diagnostic methods, and increasing their quality in limited-resource settings is of major importance. In addition, their abilities to connect to the “cloud” data storage systems and the Internet of Things (IoT) networks for collecting and sharing medical analytical data provide a trending novel research field in medical information technology.
 

Abstract:

Dr. Kobra Salimiyan rizi received the B.S. degree in Microbiology from Isfahan University (2007-2011) and the M.S. degree in medical microbiology from Tarbiat Modares University, Tehran, Iran (2011 – 2014) and her PhD degree in medical bacteriology from Mashhad University of Medical Sciences, Mashhad, Iran (2016-2021). Her research interest includes the bacterial infectious disease, Laboratory Identification of Bacteria, TB biosensors, point-of-car technologies, analytical chemistry, and biosensors for the detection of bacteria.

  • CoronaVirus Disease

Chair

Junfeng Cao

Chengdu Medical College, China

Session Introduction

Junfeng Cao

Chengdu Medical College, China

Title: Research on the mechanism of berberine in the treatment of COVID-19 pneumonia pulmonary fibrosis using network pharmacology and molecular docking
Biography:

I entered Chengdu Medical College at the age of 18 to major in clinical medicine, and I took computer simulation analysis and pharmacology as minor subjects. Currently, I am conducting research on targeted small molecules for extraction and analytical screening of natural organic plants for the treatment of COVID-19.
 
Chengdu Medical College (CMC), under the auspices of the Sichuan Provincial Government, is located in the north of the provincial capital city, Chengdu. CMC has two campuses (Xindu campus and Tianhui campus) with an area of about 198 acres, and it covers 12 MA postgraduate majors, 23 undergraduate majors and 5 three-year-program majors with an enrollment of 14,300 full-time students. The MA postgraduate majors involve 8 majors of professional master degree (Clinical Medicine, Pharmacy, Public Health, Applied Psychology, Nursing, Biology and Medicine, Public Management and Agriculture) and 4 majors of academic master degree (Clinical Medicine, Basic Medicine, Medical Technology and Marxist Theory). CMC has 2 national experimental teaching platforms, 1 medical humanistic quality education base of the Ministry of Education and 6 experimental teaching demonstration centers of Sichuan Province. CMC has 1142 full-time teachers, among which 52.34% have senior professional post and 78.69% have master or doctor degree. CMC has built 15 provincial or department-level key scientific research platforms such as Sichuan Key Laboratory, Sichuan Engineering Laboratory and Sichuan Key Research Base of Philosophy and Social Science, and it has 10 provincial and department-level first-class research teams. Since 2006, 152 projects have been approved by the National Natural Science Foundation of China and the National Social Science Foundation of China. Teachers’ academic papers
have been published in top international academic journals such as Cell, and more than 1000 papers have been indexed by SCI, EI, CPCI-S, etc. 137 academic works have been published and 155 patents have been authorized. In recent years, the school has won one first prize, five second prizes and seven third prizes for provincial and ministerial scientific andtechnological achievements.

 

Abstract:

Pulmonary fibrosis caused by COVID-19 pneumonia is a serious complication of COVID-19 infection, there is a lack of effective treatment methods clinically. This article explored the mechanism of action of berberine in the treatment of COVID-19 (Corona Virus Disease 2019, COVID-19) pneumonia pulmonary fibrosis with the help of the network pharmacology and molecular docking.
 
Methods: We predicted the role of berberine protein targets with the Pharmmapper database and the 3D structure of berberine in the Pubchem database. And GeneCards database was used in order to search disease target genes and screen common target genes. Then we used STRING web to construct PPI interaction network of common target protein. The common target genes were analyzed by GO and KEGG by DAVID database. The disease-core target gene-drug network was established and molecular docking was used for prediction. We also analyzed the binding free energy and simulates molecular dynamics of complexes.
 
Results: Berberine had 250 gene targets, COVID-19 pneumonia pulmonary fibrosis had 191 gene targets, the intersection of which was 23 in common gene targets. Molecular docking showed that berberine was associated with CCl2, IL-6, STAT3 and TNF-α. GO and KEGG analysis reveals that berberine mainly plays a vital role by the signaling pathways of influenza, inflammation and immune response.
 
Conclusion: Berberine acts on TNF-α, STAT3, IL-6, CCL2 and other targets to inhibit inflammation and the activation of fibrocytes to achieve the purpose of
treating COVID-19 pneumonia pulmonary fibrosis.